Accessibility control and machinery of immunoglobulin class switch recombination

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Accessibility control and machinery of immunoglobulin class switch recombination.

Immunoglobulin (Ig) class switching is a process by which B lymphocytes shift from production of IgM to other Ig classes and subclasses via Ig class switch recombination (CSR). Multiple cellular and molecular processes are involved in CSR. Induction of a given IgH germline transcription initiates CSR processes. Ig germline transcription is selectively activated and induced by specific cytokine(...

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Immunoglobulin class-switch recombination deficiencies

Immunoglobulin class-switch recombination deficiencies (Ig-CSR-Ds) are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect in question, the Ig-CSR-D may be combined with an impairment in somatic hypermutation (SHM). Some of the mechanisms underlying Ig-CSR and SHM have been described by studying natural mutants ...

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onychomadesis in a patient with immunoglobulin class switch recombination deficiency

immunoglobulin class switch recombination deficiencies (ig csr deficiencies) or hyper igm syndromes (higm) are a group of primary immunodeficiency diseases, characterized by defective cd40 signaling of b cells resulting into a csr and a somatic hypermutation. the affected patients are characterized with reduced serum levels of igg and iga, and normal or elevated level of igm, which lead to incr...

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Accessibility Control of Recombination at Immunoglobulin Locus

During B cell development, two somatic DNA recombination events occur at the immunoglobulin heavy chain loci: VDJ recombination and class switch recombination (CSR). VDJ recombination assembles antigen receptor genes from a pool of gene segments. CSR exchanges the μ constant region of the immunoglobulin heavy chain gene for the other isotypes (γ1, γ2a, γ2b, γ3, α or ε). In both cases, the targe...

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Parp3 Negatively Regulates Immunoglobulin Class Switch Recombination

To generate highly specific and adapted immune responses, B cells diversify their antibody repertoire through mechanisms involving the generation of programmed DNA damage. Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by the recruitment of activation-induced cytidine deaminase (AID) to immunoglobulin loci and by the subsequent generation of DNA lesions, which ar...

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ژورنال

عنوان ژورنال: Journal of Leukocyte Biology

سال: 2003

ISSN: 0741-5400

DOI: 10.1189/jlb.0702339